The technical exchange workshop was first kicked off by Liu Zumei, Product Manager of Bio-Gene. With the theme "Principles and Applications of the MED64 Microelectrode Array Recording System", she elaborated on the advantages of this system as a complete and user-friendly in-vitro extracellular field potential research tool, covering comprehensive solutions from hardware and consumables to analysis software. Combined with practical cases, she demonstrated its wide applications in areas such as synaptic plasticity, brain organoids, optogenetics and drug screening for the detection of samples like acute brain slices and cultured nerve cells. Subsequently, she delivered a presentation themed "Application of PA-QuIC in Protein Aggregation Detection", in-depth analyzing the high sensitivity and specificity of RT-QuIC technology, and expounding its value in the early diagnosis of neurodegenerative diseases such as prion diseases, Alzheimer's disease and Parkinson's disease. She also highlighted how the PA-QuIC series instruments developed by BMG LABTECH (Germany) further improve detection throughput and efficiency, providing technical support for protein misfolding research.​

Next, Associate Professor Li Xuhui from the School of Forensic Medicine, Medical Department of Xi'an Jiaotong University gave a technical exchange sharing titled "Application of MED64 Multichannel Field Potential Recording in Synaptic Plasticity and Chronic Pain Research". He pointed out that the long-term potentiation (LTP) of synaptic plasticity is the central mechanism of learning, memory and chronic pain, and the MED64 system, with its unique advantages of stable recording, long-term detection capability and high-throughput recording, serves as a powerful tool for studying this mechanism. Associate Professor Li Xuhui also shared the achievements made by his team using MED64 technology: successfully deciphering the molecular mechanisms of different types of synaptic plasticity (pre-LTP, post-LTP, LTD, synaptic tagging), clarifying the central mechanisms by which synaptic plasticity participates in the regulation of chronic pain, learning and memory in different species (mice, rats and tree shrews), and screening out drugs with analgesic effects by studying the impact of drugs on the induction or maintenance phase of LTP. Relevant achievements have been published in top international journals such as Brain, Neuropsychopharmacology and JNS, providing important scientific basis for clinical treatment.​

2025 Microelectrode Array (MEA) Technology and Neurodegenerative Disease Detection Technology Sharing Workshop has concluded successfully. 

We look forward to meeting you again at the next sharing workshop!