BMG多功能酶标仪国内用户出版物快报 (2024年7月)
本期研究亮点推介
>>>Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway
河北省中西医结合研究院,罗冰理论创新与转化国家重点实验室,石家庄亿灵药业有限公司新药评价中心联合在专业学术期刊British Journal of Pharmacology发表了题为Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway的文章,破译甘草次酸 (GA) 的潜在抗 SARS-CoV-2 机制。GA 的抗 SARS-CoV-2 作用在体外和体内均得到了验证。采用均相时间分辨荧光测定、生物膜干涉测量技术和分子对接来检查 GA 与干扰素基因人类刺激物 (hSTING) 的相互作用。免疫荧光染色、western blot 和 RT-qPCR 检测干扰素调节因子 3 (IRF3) 的核转位和 STING 靶基因水平。
科研工作者借助使用 BMG的PHERAstar FSX 多功能微孔板检测系统采用时间分辨 (TR) -荧光共振能量转移 (FRET) 测定来评估 ACE2-Spike 结合抑制活性。采用 FRET 测定法评估对 3CL 蛋白酶 (3CLpro) 的抑制活性。采用 CLARIOstar Plus 多功能微孔板检测系统评估荧光值。高通量高灵敏度BMG的PHERAstar FSX 多功能微孔板检测系统和高灵敏高度灵活的CLARIOstar Plus 多功能微孔板检测系统是用于药物筛选和药物研发的有力工具。
(原文:https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.16473)
研究领域
(共计36篇,涉及23个领域)
A comprehensive adsorption and desorption study on the interaction of DNA oligonucleotides with TiO2 nanolayer
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The cellular adaptor GULP1 interacts with ATG14 to potentiate autophagy and APP processing
香港中文大学理学院生命科学学院
Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury
吉林大学第二医院骨科
mTORC2-driven chromatin cGAS mediates chemoresistance through epigenetic reprogramming in colorectal cancer
深圳大学附属第三医院华南医院泌尿外科
1,2-bis(2,4,6-tribromophenoxy) ethane induces necroptosis via the co-competition of GAS5 and NUAK1 for miR-743a-5p in rat hepatocytes
北京大学公共卫生学院毒理学系
Polyamine Anabolism Promotes Chemotherapy-Induced Breast Cancer Stem Cell Enrichment
山东大学齐鲁医院普通外科乳腺外科
Probiotic Lactobacillus fermentum TSF331, Lactobacillus reuteri TSR332, and Lactobacillus plantarum TSP05 improved liver function and uric acid management-A pilot study
台湾高雄市佛银大学衰老与疾病预防研究中心
Gut microbiome model predicts response to neoadjuvant immunotherapy plus chemoradiotherapy in rectal cancer
首都医科大学附属北京友谊医院普外科
Very long-chain fatty acids control peroxisome dynamics via a feedback loop in intestinal stem cells during gut regeneration
四川大学华西医院
Covalent Interactions of Anthocyanins with Proteins: Activity-Based Protein Profiling of Cyanidin-3- O-glucoside
广东工业大学化工与轻工学院
ASM is a therapeutic target in dermatomyositis by regulating the differentiation of naive CD4 + T cells into Th17 and Treg subsets
四川大学全科医学中心华西医院全科科
Lactone-to-Lactam Editing Alters the Pharmacology of Bilobalide
香港中文大学医学院药学院
3,4,5-tri-O-caffeoylquinic acid attenuates influenza A virus induced inflammation through Toll-like receptor 3/7 activated signaling pathway
香港中文大学生命科学学院
Therapeutic SHPRH-146aa encoded by circ-SHPRH dynamically upregulates P21 to inhibit CDKs in neuroblastoma
首都医科大学附属北京儿童医院外科
Metagenomic insights into microbial community structure and metabolism in alpine permafrost on the Tibetan Plateau
中国科学院植物研究所植被与环境变化国家重点实验室
Bioadhesive and drug-loaded cellulose nanofiber/alginate film for healing oral mucosal wounds
海军医科大学长征医院口腔科
Osimertinib resistance-based immune prognostic related gene signature in EGFR mutant lung adenocarcinoma, in which PSMD11 promotes tumor progression
空军医科大学唐都医院
Up-regulated FOXO3/IL-10 Axis Inhibits Mitochondria-Associated Ferroptosis in Sepsis-Induced Diaphragm Dysfunction
上海交通大学医学院附属第九人民医院
Actn2 defects accelerates H9c2 hypertrophy via ERK phosphorylation under chronic stress
南京医科大学法医学教研室
Synthetic macrolides overcoming MLSBK-resistant pathogens
复旦大学中山医院生命科学学院
PKM2 aggregation drives metabolism reprograming during aging process
北京大学基础医学院生物化学与生物物理系
eIF6 Promotes Gastric Cancer Proliferation and Invasion by Regulating Cell Cycle
西南医科大学人体解剖学系
A novel hybrid lanthanide metal-organic frameworks based on porphyrin for rapid detection of iron ions
西南医科大学公共卫生学院
Significant in situ sludge yield reduction in an acidic activated sludge system
香港城市大学能源与环境学院
Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy
中国科学院上海药物研究所中国科学院受体研究重点实验室
Combination of monensin and erlotinib synergistically inhibited the growth and cancer stem cell properties of triple-negative breast cancer by simultaneously inhibiting EGFR and PI3K signaling pathways
南京农业大学兽药研究与评价中心
In Vitro Protective Effect of Pea-Derived Peptides (PPs) via the Keap1/Nrf2 Signaling Pathway on Alpha-Gliadin-Sensitizing Peptide Induced Cacao-2 Cells
郑州大学第一附属医院
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
上海交通大学Bio-X研究所
Heteroatom Doping Promoted Ultrabright and Ultrastable Photoluminescence of Water-Soluble Au/Ag Nanoclusters for Visual and Efficient Drug Delivery to Cancer Cells
河南大学物理与电子学院高等交叉学科研究院作物逆境适应与改良国家重点实验室
Growth of Cordyceps militaris cultivation and its bioactive component accumulation as affected by various single-wavelength light-emitting diodes (LED) light sources
江苏食品医药学院食品学院
Multi-mode sensing platform for gallic acid determination based on the peroxidase-like activity of magnetic Fe3O4@Co/Ni/Al-LDH nanospheres
西南医科大学公共卫生学院
Fabrication and hemostasis evaluation of a carboxymethyl chitosan/sodium alginate/Resina Draconis composite sponge
南方海洋科学与工程广东省湛江实验室海洋生物资源开发研究中心
Land Degradation Affects Soil Microbial Properties, Organic Matter Composition, and Maize Yield
东北林业大学林学院
Pocket-based lead optimization strategy for the design and synthesis of tubulin polymerization inhibitors
沈阳药科大学基于结构的药物设计与发现教育部重点实验室
Low Expression of Selenoprotein S Induces Oxidative Damage in Cartilages
西安交通大学医学部公共卫生学院
Glycyrrhetinic acid blocks SARS-CoV-2 infection by activating the cGAS-STING signalling pathway
河北省中西医结合研究院
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