BMG多功能酶标仪国内用户出版物快报 (2023年11月)
本期研究亮点推介
>>>Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
瑞典卡罗林斯卡医学院阿尔茨海默病研究中心在专业学术期刊Molecular Psychiatry上发表了题为Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models的文章,吉林大学第一医院耳鼻咽喉头颈外科参与了这项研究工作。科学家在阿尔茨海默动物模型上发现线粒体氧化磷酸化上调,跟氧化损伤和钙超载有关。随着病理发展,线粒体在突触前末梢丰度减少,脑部基础代谢率减退。在AD模型上发现线粒体功能异常出现时间先于细胞自噬损伤和突触混乱。理解病理进程能帮助找寻AD的治疗新方案。
科研工作者借助BMG的CLARIOstar plus多功能酶标仪进行线粒体能量产生,钙保留能力和活性氧产生的的分析。CLARIOstar plus多功能酶标仪高灵敏和高灵活的的荧光以及化学发光分析功能帮助科学家轻松获得相应的数据结果。
(原文:https://www.nature.com/articles/s41380-023-02289-4)
研究领域
(共计25篇,涉及19个领域)
Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure
山东大学生殖医学中心
Inhibiting NR5A2 targets stemness in pancreatic cancer by disrupting SOX2/MYC signaling and restoring chemosensitivity
上海交通大学医学院公共卫生学院单细胞组学研究中心
Identification and fine mapping of qSW2 for leaf slow wilting in soybean
辽宁省农业科学院作物研究所
Enhancing near-infrared II photodynamic therapy with nitric oxide for eradicating multidrug-resistant biofilms in deep tissues
北京化工大学生物医用材料北京实验室有机无机复合材料国家重点实验室
CTHRC1 promotes colorectal cancer progression by recruiting tumor-associated macrophages via up-regulation of CCL15
四川大学华西医院呼吸与重症医学科
Terminalia chebula Retz. aqueous extract inhibits the Helicobacter pylori-induced inflammatory response by regulating the inflammasome signaling and ER-stress pathway
中山大学药学院(深圳)
Characterization and source-apportionment of synergistic ecotoxicities of multiple pollutants based on a biosensor-biospectroscopy coupling (BBC) test battery approach
吉林大学地下水资源与环境教育部重点实验室
Active pharmaceutical ingredient-ionic liquids assisted follicular co-delivery of ferulic acid and finasteride for enhancing targeted anti-alopecia
中山大学药学院
Low-dose TNF-α promotes angiogenesis of oral squamous cell carcinoma cells via TNFR2/Akt/mTOR axis
山东大学齐鲁医学院口腔医学院牙周病科
CircMIRLET7BHG, upregulated in an m6A-dependent manner, induces the nasal epithelial barrier dysfunction in allergic rhinitis pathogenesis
海南省总医院(海南医科大学附属医院)耳鼻咽喉头颈外科
Two Chinese patients of sporadic Creutzfeldt–Jacob disease with a S97N mutation in PRNP gene
中国疾病预防控制中心病毒病预防控制所
Sphaerotilus natans hemoglobins have an NADH oxidation activity and promote the yield of limonene in an engineered E. coli strain
北京师范大学生命科学学院基因工程与生物技术北京市重点实验室
Nobiletin, an active component of Wenyang Yiqi Formula, alleviates constipation associated depression through targeting MAPT to inhibit the MAPK signaling pathway
南京中医药大学附属医院中医预防科
Ephedrine and Cocaine Cause Developmental Neurotoxicity and Abnormal Behavior in Zebrafish
华南师范大学环境研究所
Superstructural ordering in self-sorting coacervate-based protocell networks
北京化工大学生物医用材料北京实验室
Chidamide inhibits cell glycolysis in acute myeloid leukemia by decreasing N6-methyladenosine-related GNAS-AS1
中南大学湘雅医院血液科
Mechanical properties, degradation behavior and cytocompatibility of biodegradable 3vol%X (X = MgO, ZnO and CuO)/Zn matrix composites with excellent dispersion property fabricated by graphene oxide-assisted hetero-aggregation
天津工业大学材料科学与工程学院
Genetic dissection and identification of stripe rust resistance genes in the wheat cultivar Lanhangxuan 121, a cultivar selected from a space mutation population
西北农林科技大学
Development of a bioengineered Erwinia chrysanthemi asparaginase to enhance its anti-solid tumor potential for treating gastric cancer
香港理工大学应用生物及化学科技学系
Mitochondrial hypermetabolism precedes impaired autophagy and synaptic disorganization in App knock-in Alzheimer mouse models
吉林大学第一医院耳鼻咽喉头颈外科
Oridonin attenuates atherosclerosis by inhibiting foam macrophage formation and inflammation through FABP4/PPARγ signalling
广州医科大学附属第六医院
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway
电子科技大学附属肿瘤医院
Glaesserella parasuis QseBC two-component system senses epinephrine and regulates capD expression
华中农业大学动物医学院
Novel low-shrinkage dental resin containing microcapsules with antibacterial and self-healing properties
山东大学齐鲁医学院口腔医学院口腔修复科
L-glutamine sensitizes Gram-positive-resistant bacteria to gentamicin killing
暨南大学生命科学与技术学院
Novel allelic variations in Tannin1 and Tannin2 contribute to tannin absence in sorghum
山东农业大学
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